Rosh Internal Medicine Boost Practice Exam

What is the likely diagnosis for a patient who has a history of constant abdominal pain combined with weight loss?

1. Cirrhosis

2. Cholecystitis

3. Peptic ulcer disease

4. Gastroesophageal reflux disease

The correct answer is: Cirrhosis

In cases of constant abdominal pain accompanied by weight loss, cirrhosis is a significant consideration. This condition often develops over a long period due to chronic liver damage from various causes, such as alcohol abuse, viral hepatitis, or nonalcoholic fatty liver disease. As cirrhosis progresses, it can lead to abdominal pain due to complications like portal hypertension or liver failure, and the associated symptoms can contribute to weight loss due to decreased appetite and metabolic changes. Patients with cirrhosis may experience other symptoms such as jaundice, ascites, and easy bruising, which can further indicate the severity of liver dysfunction. Given the chronic nature of cirrhosis, it's not uncommon for patients to present with both abdominal discomfort and significant weight loss as the body struggles with nutritional intake and metabolism. In contrast, while cholecystitis can also result in abdominal pain, it typically presents acutely and is often associated with gallstones, leading to sudden, sharp pain rather than constant pain. Peptic ulcer disease usually presents with episodic pain rather than constant discomfort and often features a clearer pattern of pain related to meals. Gastroesophageal reflux disease generally results in heartburn or regurgitation rather than the persistent abdominal pain and significant